Services

Starting with your antigen of interest, we research and source commercially available antibodies. Optimizing conditions in your assay of interest, we rigorously assess signal-to-noise ratio delivering the best antibody for your application. 

Using confocal imaging over a range of resolutions from full-section to subcellular, we quantify your protein of interest by brain region, cell type, genotype, and treatment. Large sample sizes and carefully minimized variability give you optimal sensitivity to detect small differences. 

Detect target gene expression in intact brain tissue.  Alone, or combined with immunocytochemistry in the same experiment, Expressive provides results tha put expression in the context of brain anatomy, cell type, and subcellular location.

With a unique computer-aided approach,  we can rapidly quantify and characterize thousands of spines on hundreds of dendrites with respect to number, size, and morphology, providing a sensitive phenotypic readout of brain function.

Understand in detail the expression level and tropism of candidate vectors.  Evaluate candidate vectors with regard to their ability to deliver your therapeutic at the appropriate level in the correct cell types and brain regions.

Power your AD program with Expressive's automated plaque quantification platform.   Starting with high-quality imaging, we provide detailed statistics on plaque number, size, and location to characterize your AD model or evaluate your candidate intervention.

Our high-throughput, full-section c-Fos expression analysis platform provides a detailed spatial measure of brain activation in response to any genetic, chemical, or environmental stimulus.

Measure your protein of interest with respect to other sub-cellular organelles, structures, or proteins. Detect changes in localization as an indication of functional regulation.